原著論文

 

2019 

Homma, Y., Kinoshita, R., Kuchitsu, Y., Wawro, P., Marubashi, S., Oguchi, M., Ishida, M., Fujita, N., and Fukuda, M.

Comprehensive knockout analysis of the Rab family GTPases in epithelial cells.

J Cell Biol (2019), jcb.201810134;

 

 

2018 

Kuchitsu, Y., Homma, Y., Fujita, N.#, and Fukuda, M.#

Rab7 knockout unveiled regulated autolysosome maturation induced by glutamine starvation.  

J Cell Sci (2018) 131, jcs215442 (# co-corresponding authors)

 

 

2017 

Fujita, N.#, Huang, W., Lin, T.H., Groulx, J.F., Jean, S., Nguyen, J., Kuchitsu, Y., Koyama-Honda, I., Mizushima, N., Fukuda, M., and Kiger, A.A.#

Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy. 

Elife (2017) 6. e23367 (# co-corresponding authors)

 

 

2016

Imai, K., Hao, F., Fujita, N., Tsuji, Y., Oe, Y., Araki, Y., Hamasaki, M., Noda, T., and Yoshimori, T.

Atg9A trafficking through the recycling endosomes is required for autophagosome formation. 

J Cell Sci (2016) 129, 3781-3791. 

 

Hirano, S., Uemura, T., Annoh, H., Fujita, N., Waguri, S., Itoh, T., and Fukuda, M.

Differing susceptibility to autophagic degradation of two LC3-binding proteins: SQSTM1/p62 and TBC1D25/OATL1. 

Autophagy (2016) 12, 312-326.

 

 

2014  

Kobayashi, I., Kobayashi-Sun, J., Kim, A.D., Pouget, C., Fujita, N., Suda, T., and Traver, D.

Jam1a-Jam2a interactions regulate haematopoietic stem cell fate through Notch signalling

Nature (2014) 512, 319-323.

 

Choi, J., Park, S., Biering, S.B., Selleck, E., Liu, C.Y., Zhang, X., Fujita, N., Saitoh, T., Akira, S., Yoshimori, T., Sibley, L.D., Hwang, S., and Virgin, H.W. The parasitophorous vacuole membrane of Toxoplasma gondii is targeted for disruption by ubiquitin-like conjugation systems of autophagy. 

Immunity (2014) 40, 924-935.

 

Akaishi R, Yamada T, Kakabayashi K, Hishihara H, Furuta I, Kojima K, Morikawa M, Fujita N, and Minakami H.

Autophagy in the placenta of women with hypertensive disorders in pregnancy.

Placenta (2014) 35: 974-980.

 

 

2013  

Fujita, N.*, Morita, E.*, Itoh, T., Tanaka, A., Nakaoka, M., Osada, Y., Umemoto, T., Saitoh, T., Nakatogawa, H., Kobayashi, S., Haraguchi, T., Guan, J.L., Iwai, K., Tokunaga, F., Saito, K., Ishibashi, K., Akira, S., Fukuda, M., Noda, T., and Yoshimori, T.

Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin. 

J Cell Biol (2013) 203, 115-128. (* co-first authors)

 

Hamasaki, M., Furuta, N., Matsuda, A., Nezu, A., Yamamoto, A., Fujita, N., Oomori, H., Noda, T., Haraguchi, T., Hiraoka, Y., Amano, A., and Yoshimori, T.

Autophagosomes form at ER-mitochondria contact sites. 

Nature (2013) 495, 389-393.

 

Nakashima, A., Yamanaka-Tatematsu, M., Fujita, N., Koizumi, K., Shima, T., Yoshida, T., Nikaido, T., Okamoto, A., Yoshimori, T., and Saito, S.

Impaired autophagy by soluble endoglin, under physiological hypoxia in early pregnant period, is involved in poor placentation in preeclampsia.

Autophagy (2013) 9, 303-316.

 

Yamanaka-Tatematsu, M., Nakashima, A., Fujita, N., Shima, T., Yoshimori, T., and Saito, S.

Autophagy induced by HIF1alpha overexpression supports trophoblast invasion by supplying cellular energy. 

PLoS One (2013) 8, e76605.

 

 

2012 

Takahashi, A., Kimura, T., Takabatake, Y., Namba, T., Kaimori, J., Kitamura, H., Matsui, I., Niimura, F., Matsusaka, T., Fujita, N., Yoshimori, T., Isaka, Y., and Rakugi, H.

Autophagy guards against cisplatin-induced acute kidney injury. 

Am J Pathol (2012) 180, 517-525.

 

Shimizu, S., Takehara, T., Hikita, H., Kodama, T., Tsunematsu, H., Miyagi, T., Hosui, A., Ishida, H., Tatsumi, T., Kanto, T., Hiramatsu, N., Fujita, N., Yoshimori, T., and Hayashi, N.

Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma. 

Int J Cancer (2012) 131, 548-557.

 

 

2011 

Taguwa, S., Kambara, H., Fujita, N., Noda, T., Yoshimori, T., Koike, K., Moriishi, K., and Matsuura, Y. Dysfunction of autophagy participates in vacuole formation and cell death in cells replicating hepatitis C virus. 

J Virol (2011) 85, 13185-13194.

 

Ishibashi, K., Fujita, N., Kanno, E., Omori, H., Yoshimori, T., Itoh, T., and Fukuda, M.

Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12-5-16L2 complex. 

Autophagy (2011) 7, 1500-1513.

 

 

2010

Furuta, N., Fujita, N., Noda, T., Yoshimori, T., and Amano, A.

Combinational soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins VAMP8 and Vti1b mediate fusion of antimicrobial and canonical autophagosomes with lysosomes. 

Mol Biol Cell (2010) 21, 1001-1010.

 

Moreau, K., Lacas-Gervais, S., Fujita, N., Sebbane, F., Yoshimori, T., Simonet, M., and Lafont, F.

Autophagosomes can support Yersinia pseudotuberculosis replication in macrophages. 

Cell Microbiol (2010) 12, 1108-1123.

 

 

2009

Fujita, N., Saitoh, T., Kageyama, S., Akira, S., Noda, T., and Yoshimori, T.

Differential involvement of Atg16L1 in Crohn disease and canonical autophagy: analysis of the organization of the Atg16L1 complex in fibroblasts. 

J Biol Chem (2009) 284, 32602-32609.

 

Hayashi-Nishino, M., Fujita, N., Noda, T., Yamaguchi, A., Yoshimori, T., and Yamamoto, A.

A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation. 

Nat Cell Biol (2009) 11, 1433-1437.

 

Saitoh, T.*, Fujita, N.*, Hayashi, T., Takahara, K., Satoh, T., Lee, H., Matsunaga, K., Kageyama, S., Omori, H., Noda, T., Yamamoto, N., Kawai, T., Ishii, K., Takeuchi, O., Yoshimori, T., and Akira, S.

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. 

Proc Natl Acad Sci U S A (2009) 106, 20842-20846. (* co-first authors)

 

 

2008 

Saitoh, T.*, Fujita, N.*, Jang, M.H., Uematsu, S., Yang, B.G., Satoh, T., Omori, H., Noda, T., Yamamoto, N., Komatsu, M., Tanaka, K., Kawai, T., Tsujimura, T., Takeuchi, O., Yoshimori, T., and Akira, S.

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. 

Nature (2008) 456, 264-268. (* co-first authors)

 

Fujita, N., Hayashi-Nishino, M., Fukumoto, H., Omori, H., Yamamoto, A., Noda, T., and Yoshimori, T.

An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure. 

Mol Biol Cell (2008) 19, 4651-4659.

 

Fujita, N., Itoh, T., Omori, H., Fukuda, M., Noda, T., and Yoshimori, T.

The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy. 

Mol Biol Cell (2008) 19, 2092-2100.

 

Itoh, T., Fujita, N., Kanno, E., Yamamoto, A., Yoshimori, T., and Fukuda, M.

Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation. 

Mol Biol Cell (2008) 19, 2916-2925.

 

Fujita, N., Tamura, A., Higashidani, A., Tonozuka, T., Freeze, H.H., and Nishikawa, A.

The relative contribution of mannose salvage pathways to glycosylation in PMI-deficient mouse embryonic fibroblast cells. 

FEBS J (2008) 275, 788-798.

 

 

 

 

総説・解説

 

英文

Noda, T., Kageyama, S., Fujita, N., and Yoshimori, T.

Three-Axis Model for Atg Recruitment in Autophagy against Salmonella. 

Int J Cell Biol (2012) 2012, 389562.

 

Fujita, N., and Yoshimori, T.

Ubiquitination-mediated autophagy against invading bacteria. 

Curr Opin Cell Biol (2011) 23, 492-497.

 

Saitoh, T., Fujita, N., Yoshimori, T., and Akira, S.

Regulation of dsDNA-induced innate immune responses by membrane trafficking. 

Autophagy (2010) 6, 430-432.

 

Hayashi-Nishino, M., Fujita, N., Noda, T., Yamaguchi, A., Yoshimori, T., and Yamamoto, A.

Electron tomography reveals the endoplasmic reticulum as a membrane source for autophagosome formation. 

Autophagy (2010) 6, 301-303.

 

Noda, T., Fujita, N., and Yoshimori, T.

The late stages of autophagy: how does the end begin? 

Cell Death Differ. (2009) 16, 984-90.

 

Fujita, N., Noda, T., and Yoshimori, T.

Atg4B(C74A) hampers autophagosome closure: a useful protein for inhibiting autophagy. 

Autophagy (2009) 5, 88-89.

 

Noda, T., Fujita, N., and Yoshimori, T.

The Ubi brothers reunited. 

Autophagy (2008) 4, 540-541.

 

 

和文

朽津芳彦、藤田尚信、福田光則

『Rabによるオートファジーの制御』

実験医学 35: 2516-2523 (2017)

 

藤田尚信、吉森保

『オートファジー 〜分子機構と疾患との関連〜』

BIO Clinica 26: 269-372 (2011)

 

松永耕一、藤田尚信、吉森保

『オートファジーの駆動・制御機構の進化と疾患とのかかわり』

実験医学 27: 2930-2936 (2009) 

 

齊藤達哉、藤田尚信、吉森 保、審良静男
オートファジーと炎症
細胞 41(7): 17-20 (2009)

 

齊藤達哉、藤田尚信、吉森 保、審良静男
オートファジーによる炎症反応制御
蛋白質核酸酵素 増刊号 感染現象54(8): 1119-1124 (2009)

 

齊藤達哉、藤田尚信、吉森 保、審良静男
オートファジー関連遺伝子Atg16L1はエンドトキシンによる炎症反応を制御する
実験医学 5月号27(8) : 1247-1250 (2009) 

 

藤田尚信、松永耕一、野田健司、吉森保
哺乳類オートファジー研究の夜明け
蛋白質核酸酵素 53(16) : 2106-2021 (2008)

 

齊藤達哉、藤田尚信、吉森 保、審良静男
オートファジーと自然免疫応答
蛋白質核酸酵素 53: 2279-2285 (2008)

 

 

 

著書

 

藤田尚信『ショウジョウバエを用いたメンブレントラフィックの研究』

メンブレントラフィック(福田光則、吉森保編・化学同人)(2016) p226-235

 

Kimura, S., Fujita, N., Noda, T., and Yoshimori, T.

Monitoring autophagy in mammalian cultured cells through the dynamics of LC3.

Methods Enzymol (2009) 452, 1-12.

藤田尚信研究室 東京工業大学 科学技術創成研究院 細胞制御工学研究センター

© 2019 by Fujita Lab, Tokyo Institute of Technology